Epistem's proprietary gene expression platform (GenetRx^TM) measures the drug induced gene expression effect in response to drug therapies, thereby using molecular markers to obtain a detailed picture of the systemic effect of the drug at the molecular gene expression level to determine;

• Pharmacodynamic change
• Drug efficacy
• If the patient has a gene profile suitable for treatment

Regulatory agencies are increasingly demanding objective tests that measure pharmacologic responses to a new drug during clinical development. Gene biomarkers can inform clinicians on drug exposure, dose and scheduling, toxicity, and patient selection.  Epistem has worked with many of the top 20 Pharmaceutical compnaies providing gene expression biomarker information to drug development programs.  We have supported over 20 clinical trials to date in our GCLP accredited laboratory.  We are able to analyse a broad range of different sample types including a technique we have pioneered to obtain gene expression information from single plucked human hairs. 

For more information on the gene expression services we offer to support drug development programs within clinical settings, please click here